We are a highly dedicated, translational and internationally wellconnected research group investigating the mechanisms of the human antibody response to infectious agents and their translation into clinical practice (e.g. Zehner et al., Immunity 2023; Kreer & Zehner et al., Cell
2020; Ehrhardt & Zehner et al., Nat. Med. 2019). Our work aims to define fundamental mechanisms of human antiviral immunity and to translate these insights into next-generation therapeutic strategies.
A major research focus of our laboratory is the human antibody response to Human Cytomegalovirus (HCMV)—a globally prevalent pathogen with high clinical relevance. We aim to dissect the molecular interfaces between HCMV and the immune system, determine how potent neutralizing antibodies recognize viral entry complexes, and uncover the strategies the virus employs to escape these responses. A central component of our program is the isolation and in-depth characterization of human monoclonal antibodies with unique functional properties.
Our research environment offers access to state-of-the-art technologies, including advanced infection models, single-cell antibody discovery platforms, and interdisciplinary collaborations with clinicians, structural biologists and international partners. These resources enable mechanistic projects with direct translational potential, including the identification of therapeutic lead candidates.
You will be embedded in an ambitious, supportive and excellence-driven scientific environment that encourages independent thinking, rigorous experimentation and high-impact research. Your contribution will advance our understanding of viral immune evasion and help shape new strategies for preventing and treating HCMV and other infectious diseases, and may inform future antibody-based interventions against HCMV and related pathogens.
